In fact, a lot of transgenic and knockout mice are utilized to investigate the NNK-induced lung carcinogenesis. It blocks a gene  known as JAK2. By blocking JAK2 ruxolitinib slows down or stops the cancer cells expanding and dividing. Navitoclax is a focused drug. It works by blocking proteins named BCL-2. https://gw406400876.blogoxo.com/26250694/mouse-an-overview