Gastrointestinal (GI): NSAIDs that block COX-one activity have correlations with GI difficulties because of the inhibition on the synthesis of gastroprotective agents which include PGE2 along with other prostaglandins. This inhibition causes lowered mucin generation by gastric epithelial cells, much less bicarbonate secretion, and less epithelial mobile turnover, between other https://hilaryt467xvx6.vigilwiki.com/user