Pentobarbital will reduce the level or outcome of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. pentobarbital will lessen the extent or outcome of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Unknown. Remark: Barbiturates may possibly boost adverse effects, including respiratory depression, made by harmful dose... https://archbishopf442ilo6.wiki-promo.com/user